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Mutations in conserved residues interfere with binding of these proteins to ubiquitin, but the functional consequences are unclear in the case of ABINs as their actual function is still a matter of debate. Views Read Edit View history. Finally, IKK has also been shown to phosphorylate and induce the degradation of the transcription factor FOXO3a, which plays an important role in controlling cell proliferation and survival, therefore promoting tumorigenesis Hu et al. In females, the most characteristic feature of the disease is a dermatosis that usually begins after birth and evolves according to a stereotyped sequence. Unfortunately, at the moment the identity of the physiological substrates of CylD is still unclear. EC number Enzyme superfamily Enzyme family List eaf ggaaaa ikk enzymes.


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Regarding the kinase subunits, it rapidly became clear that they differ in their substrate specificities and, as a result, have distinct biological functions. Miller BS, Zandi E This phosphorylation probably leads to a conformational change and to kinase activation.

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Trends Cell Biol In females, the most characteristic feature of the disease is a dermatosis that usually begins after birth and evolves according to a stereotyped sequence. IKK1-deficient mice exhibit abnormal development of skin and skeleton.
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